I love some of the suggestions here! Thanks everyone!
I just wanted to add that if you are looking for some quick wins, Nessus (or OpenVAS) in command-line mode can be used to scan for just one vulnerablity quickly across an entire infrastructure. This is a very reliable and fast way to hit a critical vulnerability to exploit.
I recommend building a small list of nasty vulnerabilities such as the list built here -- http://code.google.com/p/pentest-bookmarks/wiki/BookmarksList -- labelled under "MSF Exploits or Easy".
It's better to sort your most dangerous exploits that match the target infrastructure (what you know about it from recon activities) by the most dangerous and easiest to find first. It's silly to run OpenVAS, Nessus, or Rapid7 against "all vulnerabilities" because it's a waste of time and bandwidth. This is usually a custom process, and requies a little experience and domain-specific knowledge.